EPIEFFECT is a lyophilized human placental-based allograft membrane that includes the amnion layer, intermediate layer, and chorion layer.

EPIEFFECT is  intended for use as a barrier to provide a protective environment in acute and chronic wounds.

EPIEFFECT Product Benefits

Product Advantages

  • Easy to apply
  • Shelf-stable*
  • 5-year shelf life
  • Terminally sterilized for additional level of safety
  • Compatible with compression therapy, Negative Pressure Wound Therapy (NPWT) and Hyperbaric Oxygen Therapy (HBOT)
  • Contains 300+ regulatory proteins1

*See Instructions for Use

Clinical Use Examples

The following clinical applications demonstrate the wide range of EPIEFFECT:

  • Acute Wounds
  • Chronic Wounds
  • Post-Debridement
  • Dehisced Wounds
  • Diabetic Foot Ulcers (DFUs)
  • Venous Leg Ulcers (VLUs)
  • Pressure Ulcers (PUs)
  • Mohs Repair
  • Deep or Tunneling Wounds

    Repositionable after hydration

    0.6 mm thickness**

         **Nominal when dry

    EPIEFFECT Product Overview

    Making a Difference

    EPIEFFECT Processing & Details

    EPIEFFECT is processed using PURION, a unique patented method for placental-based allografts that is in accordance with the American Association of Tissue Banks (AATB) standards. The product is derived from placental tissue donated by healthy, consenting mothers who have given live Caesarean section birth in the US.

    MIMEDX’s PURION patented process preserves extracellular matrix components, including regulatory factors and other matrix-associated proteins. For an additional level of safety, the product is terminally sterilized.

    The PURION process has been optimized for retention of the Intermediate Layer (IL). Separation of the amnion and chorion, with attached IL (Figure 1), ensures thorough cleansing of each layer prior to lamination into the tri-layer final configuration (Figure 2).

    1. MIMEDX Internal Report. MM-RD-00101, Development of Lyophilized Human Amnion Chorion Membrane.

    Figure 1: Configuration During Cleansing Process

    Figure 2: Tri-layer Final Configuration

    EPIEFFECT (Q4278)

    Lyophilized Human Placental-Based Allograft Membrane
    LE-5230 2 cm x 3 cm sheet 6 850046045004
    LE-5350 3 cm x 5 cm sheet 15 850046045028
    LE-5770 7 cm x 7 cm sheet 49 850046045080
    LE-5714 7 cm x 14 cm sheet 98 850046045158


    Application Guide

    Product Brochure

    MIMEDX Advantage

    We improve people’s health and lives through innovation that delivers solutions for patients and caregivers. With a wide variety of allograft configurations, clinicians can choose the product that best meets their treatment objectives.

    Healthcare Professionals

    MIMEDX offers unique value to clinicians across sites of care. With a broad support system, we offer services to support needs relating to reimbursement and coverage, product access and cost containment, education, patient information, and clinical applications.

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