Solutions in Burn Treatments

Advanced Placental-Based Allografts When Patients Are in Need

Burns are a major source of injury that, in the absence of care, can lead to lifelong functional loss and disfigurement. While split thickness skin autografts are the current standard of care for deep partial and full-thickness burns, this approach is associated with considerable complications. AMNIOBURN^®, an advanced membrane allograft, provides an alternative with strong clinical and scientific evidence for the treatment of burns.

Video Testimonials

Plastic Surgeon Perspective

A plastic surgeon’s perspective on AMNIOBURN Placental-Based Allografts

Dr. David Adcock

Potential Areas of Use:

Points of articulation
Head/face
Hands
Genitals
Bone & Tendon
Feet

AMNIONBURN Advantages:

Provides a protective barrier and environment that supports the healing cascade
Protects the wound bed to aid in the development of granulation tissue
Provides a human biocompatible extracellular matrix (ECM) and contains 300+ regulatory proteins^1-3
Shelf-stable* with a 5-year shelf life
Compatible with negative pressure wound therapy (NPWT) and hyperbaric oxygen therapy (HBOT)

*See instructions for use

Case Studies:
How Physicians Use Our Products

Case study 1

**Full-Thickness Hand Burns to Fingers Bilaterally Treated With DHACM*⁴**

Full-thickness hand burns to fingers bilaterally initial debridement

Full-thickness hand burns to fingers bilaterally complete healing postop day 38

Full-thickness hand burns to fingers bilaterally postop day 115 with no contractures and minimal scarring

Full-thickness hand burns to fingers bilaterally initial debridement

Full-thickness hand burns to fingers bilaterally complete healing postop day 38

Full-thickness hand burns to fingers bilaterally postop day 115 with no contractures and minimal scarring

*This case used AMNIOBURN DHACM.

Case study 2

**Superficial Partial-Thickness Facial Burn Treated with dHACM*⁴**

Initial debridement (left lateral)

Initial debridement (anterior)

Postop Day 7 status-post DHACM application

Complete closure

*This case used AMNIOBURN DHACM.

Case study 3

Full-Thickness Burn to Limb Treated With Fenestrated DHACM+ NPWT⁵**

**This case used EPIXL FENESTRATED DHACM which was discontinued in 2021.

CAD = coronary artery disease, COPD = chronic obstructive pulmonary disease, DM = diabetes mellitus, HTN = hypertension, LLE = left lower extremity, NPWT = negative pressure wound therapy, STSG = split thickness skin graft

Surgical Product Portfolio: Advanced Placental-Based Allografts

MIMEDX offers a portfolio of advanced placental-based allografts in the surgical setting.

	AMNIOFIX	AMNIOBURN	AMNIOCORD	AXIOFILL	AMNIOEFFECT
Complex Soft-Tissue Deficit	✓	✓	✓	✓	✓
Large Area Coverage	✓	✓		✓	✓
Affix Product with Suture*			✓		✓
Product Thickness Desired			✓	✓	✓
Exposed Bone, Tendon, or Hardware	✓	✓	✓		✓
Reposition Product after Hydration	✓	✓	✓	✓	✓
Minimally Invasive Procedures	✓		✓		✓
Fenestrated Configuration to Allow Transfer of Exudate	✓

*Not intended for use as a load bearing tissue.

Resources

Burn Casebook and Peer-Reviewed Publication Abstract

download

References

Koob TJ, Lim JJ, Massee M, Zabek N, Denozière G. Properties of dehydrated human amnion/chorion composite grafts: Implications for wound repair and soft tissue regeneration. J Biomed Mater Res B Appl Biomater. 2014;102(6):1353-1362.
Lei J, Priddy LB, Lim JJ, Massee M, Koob TJ. Identification of Extracellular Matrix Components and Biological Factors in Micronized Dehydrated Human Amnion/Chorion Membrane. Adv Wound Care (New Rochelle). 2017;6(2):43-53.
MIMEDX Internal Report. MM-RD-00086, Proteome Characterization of PURION Processed Dehydrated Human Amnion Chorion Membrane (dHACM) and PURION PLUS Processed Dehydrated Human Umbilical Cord (dHUC) Allografts.
Natasha Ahuja, Richard Jin, Colin Powers, Alexandria Billi, and Kathryn Bass, Pediatric Surgeons, Buffalo, NY.
W. Dotie Jackson, MD, Plastic and Reconstructive Surgery, Jackson, MS.