What is EPIFIX?

EPIFIX® is a placental tissue allograft composed of dehydrated human amnion/chorion membrane (DHACM). It is available in sheet and mesh/fenestrated configurations in a variety of sizes to reduce wastage.

Product Application & Experience Videos

EPIFIX is backed by the most Level I publications among placental-based allografts. The quality of MIMEDX RCTs was evaluated and validated in an assessment initiated by the Agency of Healthcare Research & Quality.1

Protective Environment

EPIFIX acts as a barrier and protects the wound bed to aid in the development of granulation tissue in acute and chronic closures.

Regulatory Proteins

EPIFIX provides a biocompatible human extracellular matrix and contains 300+ regulatory proteins.2-4

Product Advantages

  • Demonstrated statistically significant outcomes vs. SOC solutions & other skin substitutes
  • Human-derived
  • Multiple configurations available for varying demands depending on wound or surgical application desired
  • Simple storage and application
  • Cost effective: Demonstrated savings in cost and utilization5,6
  • Compatible with negative pressure wound therapy (NPWT) and hyperbaric oxygen therapy (HBOT)

Clinical Use Examples

EPIFIX has been adopted by multiple clinical specialties in a variety of applications:

  • Acute Wounds
  • Chronic Wounds
  • Debridements
  • Dehisced Wounds
  • Diabetic Foot Ulcers (DFUs)
  • Venous Leg Ulcers (VLUs)
  • Pressure Ulcers (PUs)
  • Mohs repair

    Making a Difference

    EPIFIX is the amniotic skin substitute with an unprecedented depth of clinical data support. Learn how adding EPIFIX to your treatment protocols can impact you and your patients.

    EPIFIX Processing & Details

    EPIFIX is processed using PURION, a unique patented method for placental-based allografts that is in accordance with the American Association of Tissue Banks (AATB) standards. The product is derived from placental tissue donated by healthy, consenting mothers who have given live Caesarean section birth in the US.

    MIMEDX’s patented PURION process preserves extracellular matrix components, including regulatory factors and other matrix-associated proteins. For an additional level of safety, the product is terminally sterilized.


    1. Snyder DL, et al. Agency for Healthcare Research and Quality. https://www.cms.gov/Medicar…. Published February 2020. Accessed October 13, 2021.
    2. Koob TJ, Lim JJ, Massee M, Zabek N, Denozière G. Properties of dehydrated human amnion/chorion composite grafts: Implications for wound repair and soft tissue regeneration. J Biomed Mater Res B Appl Biomater. 2014;102(6):1353-1362.
    3. Lei J, Priddy LB, Lim JJ, Massee M, Koob TJ. Identification of Extracellular Matrix Components and Biological Factors in Micronized Dehydrated Human Amnion/Chorion Membrane. Adv Wound Care (New Rochelle). 2017;6(2):43-53.
    4. MIMEDX Internal Report. MM-RD-00086, Proteome Characterization of PURION Processed Dehydrated Human Amnion Chorion Membrane (dHACM) and PURION PLUS Processed Dehydrated Human Umbilical Cord (dHUC) Allografts.
    5. Armstrong DG, Tettelbach WH, Chang TJ, et al. Observed impact of skin substitutes in lower extremity diabetic ulcers: lessons from the Medicare Database (2015-2018). J Wound Care. 2021;30(Sup7):S5-S16.
    6. Tettelbach WH, Armstrong DG, Chang TJ, et al. Cost-effectiveness of dehydrated human amnion/chorion membrane allografts in lower extremity diabetic ulcer treatment. J Wound Care. 2022 Feb 1;31(Sup2):S10-S31


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    Product Brochure – HOPD & WCC

    Product Brochure – Physician Office

    Application Guide

    EPIFIX (Q4186)

    Dehydrated Human Amnion/Chorion Membrane


    GS-5140 14 mm disk 1.5 855310003087
    GS-5160 16 mm disk 2 855310003001
    GS-5180 18 mm disk 2.5 855310003414
    GS-5024 24 mm disk 4.5 855310003391
    GS-5220 2 cm x 2 cm sheet 4 855310003421
    GS-5230 2 cm x 3 cm sheet 6 855310003018
    GS-5240 2 cm × 4 cm sheet 8 855310003438
    GS-5330 3 cm × 3 cm sheet 9 855310003445
    GS-5340 3 cm × 4 cm sheet 12 855310003452
    GS-5440 4 cm × 4 cm sheet 16 855310003025
    GS-5350 3 cm × 5 cm sheet 15 855310003469
    GS-5460 4 cm × 6 cm sheet 24 855310003476
    GS-5560 5 cm × 6 cm sheet 30 855310003650
    GS-5770 7 cm × 7 cm sheet 49 855310003032
    ES-2300 2 cm x 3 cm mesh sheet 4 855310003766
    ES-3300 3.5 cm x 3.5 cm mesh sheet 8 855310003483
    ES-3500 3 cm x 5 cm mesh sheet 10 855310003858
    ES-4400 4 cm x 4.5 cm mesh sheet 10.2 855310003872
    ES-5500 5 cm x 5.5 cm mesh sheet 16.1 856019007062

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