Cranioplasty in AMNIOFIX Recipients


Neurosurgeons report that dissections during cranioplasties for skull cap replacement can be time intensive and include risks to the patient when following conventional methods.1

Peer-reviewed RCTs and other studies have reported favorable results in patients undergoing dural repair in cranial and spine surgeries with human amniotic membrane allografts.2,3

In a recent peer-reviewed study, AMNIOFIX was used as a protective barrier to support the healing cascade during emergent craniectomies.4

Key results during subsequent cranioplasty in AMNIOFIX recipients:4


  • Under 3 minutes dissection time for skull flap replacement
  • Minimal dural fibrosis in 86% of patients
  • No operative complications
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AMNIOFIX is a human amnion / chorion membrane that provides a protective barrier to support the healing cascade. The allograft contains 300+ regulatory proteins.5-7

  1. Griessenauer CJ, et al. World Neurosurg. 2015;84(6):2059-2063.
  2. Shah Z, et al. Surg Neurol Int. 2022;13:505. Published 2022 Nov 4.
  3. Subach BR, et al. Adv Orthop. 2015;2015:501202.
  4. Endicott L, et al. J Wound Care. 2023;32(10):634-640
  5. Koob TJ, et al. J Biomed Mater Res B Appl Biomater. 2014;102(6):1353-1362.
  6. Lei J, et al. Adv Wound Care (New Rochelle). 2017;6(2):43-53.
  7. MIMEDX Internal Report. MM-RD-00086.