Chronic Wound Healing

chronic wound healing

Our products help patients overcome chronic wounds and injuries

Physicians encounter a variety of wound types on a daily basis, including acute wounds caused by surgical intervention, trauma and burns, as well as chronic wounds that are delayed in closing compared to healing in an otherwise healthy individual. Chronic wounds include diabetic foot ulcers, venous leg ulcers, pressure ulcers, and arterial ulcers. Currently MiMedx® is focused on two primary chronic wound markets: venous leg ulcers and diabetic foot ulcers.

The physician’s goal when treating traumatic wounds is to heal the wound while allowing the patient to retain natural function in the area of the wound with minimal scarring and infection. If a wound becomes infected, it can lead to a loss of limb or life, and physicians want to close the wound as quickly as possible to minimize this risk. Patients with chronic wounds likely have comorbidities that complicate or delay the healing cascade.  

The healing cascade is as follows:
Injury: Inflammation, proliferation, and remodeling    

Normal soft tissue injuries heal in three main phases.

non-healing wounds

Chronic injuries stall in the inflammatory phase


normal wound healing

In order to move the patient to healing, the physician must progress the wound into the proliferative phase of healing. The physician may first attempt to close the wound by deploying the following tactics: ensuring adequate blood flow, sharp debridement, offloading or compression, controlling infection, applying standard moist wound healing and dressings. If these treatments do not work, then the physician will evaluate to see if more advanced techniques and product are needed to restart the healing process. This may include negative pressure device, xenografts, dermal allograft, culture skin substitutes, and more recently, amniotic membranes. The goal is to return the patient to a healing rate that is as close to normal healing as possible.


Acute Wound Healing


Plastic Surgery/ Scar Revision

Scar revision is surgery to improve or reduce the appearance of scars. It also restores function, and corrects skin changes (disfigurement) caused by an injury, wound, or previous surgery.  Scar tissue forms as skin heals after an injury or surgery. The amount of scarring may be affected by the wound size, depth, and location, the person’s age, heredity, and skin characteristics including skin color (pigmentation). Surgery involves excision of the scar and careful closure of the defect. Sometimes skin grafts are also used, depending on the extent and depth of the scar (for instance a burn scar).


Sports Medicine


Sports Medicine is a broad description of the repair and reconstruction of various soft-tissue injuries in or around joints caused by traumas, or chronic conditions brought about by repeated motion in active individuals and athletes. Sports medicine may include various anatomical locations, mainly knee, shoulder and elbow, but this can be broadened to include foot and ankle injuries (such as Achilles tendon rupture) and even hand and wrist injuries. The main types of injuries include tendinopathies, tendinitis, tendinosis, tendon and ligament sprains, and ruptures. Non-surgical options also include physical therapy, bracing, and injections of anti-inflammatory drugs to inflamed tendons in areas including elbows (tennis or golfer’s elbow), knees (jumper’s knee), shoulders (rotator cuff), ankles (Achilles tendon), and feet (plantar fasciitis)


Surgical Applications



The AmnioFix® technology is being used as a graft to provide a barrier to reduce the amount of scar tissue formation, provide a local anti-inflammatory and help with the soft tissue healing of the area. A reduction of scar tissue is necessary if the patient needs to have an additional surgical procedure in the future as it may facilitate the re-access to the surgical site as well as help with scar attachment to the spinal dura. The graft may be used in a variety of spinal procedures including: Laminectomies, Discectomies, posterior spinal fusions, and anterior spinal fusions.


Obstetrics and Gynecological (OB/GYN) surgical procedures encompass the treatment of diseases that may be related to the fertility of the female, pain caused by the reproductive system or cancer in the reproductive system. These procedures include the removal of uterine fibroids (myomectomy), removal of ovarian cysts, tubal ligations, endometriosis treatments, removal of some cancerous or non-cancerous tumors, and vaginal slings. These procedures may be completed through a transvaginal, abdominal or laproscopical approach.  

General surgery

General surgical procedures include procedures related to the abdominal cavity. These include the intestines, stomach, colon, liver, gallbladder, appendix, bile ducts and thyroid glands. The amniotic membrane may be laid to enhance the healing of the soft tissue, suture line or anastomosis in open or laparoscopic procedures including hernia repairs and other general surgical procedures. AmnioFix® should not be used as a load bearing graft in these procedures.